Arizona Sheriff Joe Arpaio want to throw down with George Lopez. Was it something GLo said? Absolutely. During his HBO standup special over the weekend, Lopez ripped into Arpaio over his anti-immigration policies.

Specifically, he said, and I quote, "Sheriff Joe in Arizona, [eff] you." Here's fan video of Lopez's attack. But be forewarned: F-bombs abound...

Well, Sheriff Joe has issued a response, basically saying 'come down here and say it to my face.'

Glo's publicist says Lopez would have no further comment. Maybe he's just going to let his fists do the talking? I doubt that's going to happen. But if they were to throw down, who you got?